Nanoparticles Toxicity and Biocompatibility Tests

IJL – UMR 7198 – CNRS-University of Lorraine, Nancy, France

*Corresponding author: Solenne Fleutot, IJL – UMR 7198 – CNRS-University of Lorraine, Nancy, France, E-mail: [email protected]
Received: September 11, 2020
Published: September 28, 2020

ABSTRACT

The toxicity of inorganic nanoparticles is a key issue for their development in the biomedical field. There are many tests to determine if a compound is harmful to the body, but some are applied more than others to nanoparticles. This is the case of the MTT and XTT tests which count living cells or of the TUNEL test which analyzes DNA fragments and detects cellular apoptosis. Cytometry techniques – flow and laser scanning- allow examining the evolution of the cell- life cycle while the damage suffered by DNA will rather be analyzed by the comets method.

KEYWORDS: Toxicity tests; Nanoparticles; SPIONs