Formulation And Evaluation Of Soapfilm Incorporated with Green Synthesized Azadirachta indica Silver Nanoparticles

¹Professor, Department of Pharmaceutics, Sri Ramakrishna Institute of Paramedical Sciences, India

^2,3M.Pharm, Department of Pharmaceutics, Sri Ramakrishna Institute of Paramedical Sciences, India

*Corresponding author: Dr. J Bagyalakshmi, Professor, Department of Pharmaceutics, Sri Ramakrishna Institute of Paramedical Sciences, College of Pharmacy, Tamil Nadu, Coimbatore- 44, India, E-mail: [email protected]

Received Date: May 16, 2024

Publication Date: June 15, 2024

Citation: Bagyalakshmi J, et al. (2024). Formulation And Evaluation Of Soapfilm Incorporated with Green Synthesized Azadirachta indica Silver Nanoparticles. Nanoparticle. 5(1):13.

Copyright: Bagyalakshmi J, et al. © (2024).

ABSTRACT

The present research aimed at developing the formulation and evaluation of soap film incorporated with green synthesised Azadirachta indica silver nanoparticles for its anti-bacterial activity. SEM analysis OF Azadirachta indica silver nanoparticles was performed for the study. SEM images of soap impregnated with silver nanoparticles exhibited spherically agglomerated particles due to the presence of soap. Antibacterial studies of Azadirachta indica silver nanoparticles were done in this study. The bactericidal properties of soap AgNPs were confirmed in studies against gram-positive (Staphylococcus Aureus) and gram-negative (E. coli) bacterial strains. For silver nanoparticles, the highest concentration of 100 µg/ml showed activity ranging between 20 for E. coli and 19 mm zone of inhibition for Staphylococcus Aureus. Silver nanoparticle-impregnated biomedical fibre showed efficient antimicrobial activity. It is reported that silver nanoparticles have the advantage of high anti-microbial activity even at low concentrations. The antibacterial study for Azadirachta indica silver nanoparticles was conducted in both gram-positive and gram-negative bacteria. The results were found that both gram-positive and gram-negative bacteria showed good antibacterial activity. But by comparison, the Azadirachta indica silver nanoparticles showed more effect in gram-positive bacteria. Formulation and optimisation of different types of soap films were carried out in this study. Different types of soap formulations were formulated by using sodium hydroxide and potassium hydroxide. Among this formulation, the soap containing sodium hydroxide was used because the soap containing potassium hydroxide was irritating to the skin. Another reason was the potassium hydroxide-containing soap didn't provide the texture of a film. The study revealed the efficacy of the synthesis of silver nanoparticles (AgNPs) using green principles and its potential application in health and the environment.

Keywords: Azadirachta indica, Silver Nanoparticles, Green Synthesis, Antibacterial Activity.